The 2PO-series protocol droid was a model of protocol droids produced by Cybot Galactica. The 2PO-series was succeeded by the popular 3PO-series protocol droid.

Melnea Arnthout owned a 2PO-series droid on Tatooine, which served as an ambassador between colonists and the native Jawas, using its translation protocols to translate Basic into Jawaese.