In 22 BBY, a Munificent-class star frigate was used by the Confederate General Grievous. Grievous used the frigate when he was attempting to track Jedi Knight Anakin Skywalker's position in Confederate space.
In 22 BBY, Jedi Knight Anakin Skywalker was in the suspected confederate space. R3-S6 triggered the Grievous's Jedi tracking beacon. This ship went into space, together with another ship. Anakin Skywalker was rescued, and the Vulture droids, who were the pursuit, finally exploded in the ship's engines.