- "We consider our selves neutral in this war, but we will do what we must for the good of our economy."
- ―Harko Vane
During the Clone Wars, Vane declined the Galactic Republic's ultimatum to stop supplying weapons to the Confederacy of Independent Systems and was soon killed after his transport, the Valiant, was secretly sabotaged by Dooku's best assassin and secret Sith apprentice, Asajj Ventress, in an effort to frame the Republic and Jedi Order for the crime and pull the House of Vane over to the Separatists' side.
In revenge for his father's death, his son Tofen engaged the Republic forces in battle, profiling himself as a fighter ace, but finally Anakin Skywalker, who greatly respected Tofen, managed to raise doubts about Harko's demise. In the end, Dooku's duplicity was discovered and the Count banished from the House by Harkon's widow Elodore.
- The Clone Wars 10: Hero of the Confederacy, Part 1 (First appearance)
- The Clone Wars 11: Hero of the Confederacy, Part 2 (Mentioned only)
- The Clone Wars 12: Hero of the Confederacy, Part 3 (Mentioned only)