During the Clone Wars, Karis was recognized by her master Talzin as one of the greatest warriors of her Nightsister clan, alongside fellow sister Naa'leth.[4] When Asajj Ventress returned home to Dathomir, Karis was ordered to accompany her and Naa'leth to Serenno in an attempt to assassinateCountDooku in retribution for his betrayal of Ventress, though they were defeated. Soon after the failed attack on Count Dooku, the Count sent GeneralGrievous to the planet of Dathomir and launched an attack. A vulture droid fired a missile that lead a chain reaction of falling statues from the Temple of the Nightsisters.
Karis was the first person to suffer a casualty because that was the ambush attack that started the Battle of Dathomir against the Confederacy of Independent Systems when a statue (that fell when shot by a droid bomber) crushed her. Asajj Ventress managed to pull her out but Karis said her last few words about leading the Nightsisters to victory, and died.[4]