- "Your aqua droids are no match for the Mon Calamari. What makes you think these secret weapons you've brought from your homeworld will fare any better?"
- ―Nossor Ri, expressing doubts about the Hydroid Medusas
Karkaris was the homeworld of the aquatic Karkarodon species and the Hydroid Medusa, semi-organic beings engineered by the Karkarodons. It was located in a star system that neighbored the planet Mon Cala, home of the Mon Calamari and Quarren. During the Clone Wars between the Galactic Republic and the Confederacy of Independent Systems, Separatist Commander Riff Tamson had Karkarodon enforcers and Hydroid Medusas sent from Karkaris to aid him in fighting the Republic and the Mon Calamari on Mon Cala.