The Ministry of Internal Security was one of four central ministries managed by the Supreme Chancellor during the Old Sith Wars alongside the ministries for defense, economic development, and jurisprudence.
During the height of the Clone Wars the ministry was re-established by Supreme Chancellor Palpatine. The organization was created to protect the lives of senators as well as other government officials. The Ministry converted several holding facilities into safehouses for its purposes. It denied the destruction of one of its facilities despite the destruction of the safehouse where Lavina Wren was located at which was the result of foul play. This caused many to question the MIS's activities and its true nature.