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A retrovirus was an RNA virus that was duplicated in a host cell to produce DNA from its RNA genome. Darth Tenebrous invented his own retrovirus and injected it into himself to turn his Midi-chlorians into Maxi-chlorians.

The voxyn, a creature genetically engineered by the Yuuzhan Vong, had its paws coated in a slime layer containing hundreds of retroviruses, making a rake with the claws fatal.

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