The canyon consisted of steep slopes and high cliffs and walls. An Imperial Enclave was stationed at this barren location. Despite the scarcity of vegetation and life, a sub-species of wampa, called the cliff wampa, was known to live there.
Dash Rendar visited Smuggler's Canyon on his quest to find Boba Fett and his cargo of Han Solo frozen in Carbonite. He eventually found Fett and managed to defeat him in an air duel, damaging his ship, Slave I, before Fett escaped.