During a battle on Umbara, during the Clone Wars around 21 BBY, a clone trooper named Hardcase stepped on one of the vines; the vine retaliated by picking up Hardcase and swinging him about. Although it let Hardcase go, it picked up another trooper and despite the blaster shots it received from the other clones, it chewed the clone up. However, it met its demise when it tried to eat another clone trooper by the name of Fives. Fives activated a grenade and tossed it to one of the vixus' tentacles which it then swallowed. The grenade exploded, killing the vixus and saving Fives.
A second Vixus was used in the capture of Jedi GeneralPong Krell. As Krell slaughtered dozens of clones, Tup came up with a plan to capture the General in a vixus. After having been taunted by Tup, the general unknowingly ran towards the clone trooper and ended up being caught in its tentacles. Despite slicing off many of the vixus's tentacles and later killing it, the general was shot with stun bullets from a Blaster rifle causing him to fall down heavily weakened. The clones later arrested Krell, and eventually one named Dogma shot and killed the general.